Scientist Will Rodman is determined to find a cure for Alzheimer’s, the disease which has slowly consumed his father. Will feels certain he is close to a breakthrough and tests his latest serum on apes, noticing dramatic increases in intelligence and brain activity in the primate subjects – especially Caesar, his pet chimpanzee.
Caesar and his apes are forced into a deadly conflict with an army of humans led by a ruthless Colonel. After the apes suffer unimaginable losses, Caesar wrestles with his darker instincts and begins his own mythic quest to avenge his kind. As the journey finally brings them face to face, Caesar and the Colonel…
A group of scientists in San Francisco struggle to stay alive in the aftermath of a plague that is wiping out humanity, while Caesar tries to maintain dominance over his community of intelligent apes.